abstract：:I am deeply grateful and honored to receive the 2006 Distinguished Scientist Award from the Heart Rhythm Society. Many outstanding individuals have received this award since it was established in 1982, and it is humbling to realize that my small feet are walking in the footsteps of these giants. I would be remiss if I...

journal_title：Heart rhythm

authors： Ideker RE

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The rapid evolution of implantable cardioverter-defibrillator (ICD) leads has resulted in thinner active fixation leads. While these advances have made the leads more versatile, new configurations may be associated with unforeseen complications. OBJECTIVE:The purpose of this study was to determine the incid...

journal_title：Heart rhythm

authors： Danik SB,Mansour M,Singh J,Reddy VY,Ellinor PT,Milan D,Heist EK,d'Avila A,Ruskin JN,Mela T

更新日期：2007-04-01 00:00:00

abstract：:Atrial fibrillation is a marker for worse outcomes in patients with heart failure and requires careful, individualized management. Anticoagulation and rate control are important. Routine use of antiarrhythmic drug therapy for maintenance of sinus rhythm carries concerns of risk and limited efficacy. Catheter ablation ...

journal_title：Heart rhythm

authors： Stevenson WG,Tedrow U

更新日期：2007-03-01 00:00:00

abstract：:Pulmonary vein antrum isolation offers safe and effective treatment of atrial fibrillation by eliminating the potential triggers of this arrhythmia. The pulmonary vein antra encompass, in addition to the pulmonary veins, the left atrial roof and posterior wall and, in the case of the right pulmonary vein antra, a port...

journal_title：Heart rhythm

authors： Kanj M,Wazni O,Natale A

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The concept that the interval between the peak (T(peak)) and the end (T(end)) of the T wave (T(p-e)) is a measure of transmural dispersion of repolarization time is widely accepted but has not been tested rigorously by transmural mapping of the intact heart. OBJECTIVES:The purpose of this study was to test ...

journal_title：Heart rhythm

authors： Opthof T,Coronel R,Wilms-Schopman FJ,Plotnikov AN,Shlapakova IN,Danilo P Jr,Rosen MR,Janse MJ

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Sudden infant death syndrome (SIDS) is one of the leading causes of death during the first year of life. Long QT syndrome (LQTS)-associated mutations may be responsible for 5% to 10% of SIDS cases. We recently established CAV3-encoded caveolin-3 as a novel LQTS-associated gene with mutations producing a gain...

journal_title：Heart rhythm

authors： Cronk LB,Ye B,Kaku T,Tester DJ,Vatta M,Makielski JC,Ackerman MJ

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Magnetic fields may interfere with the function of cardiac pacemakers and implantable cardioverter-defibrillators (ICDs). Neodymium-iron-boron (NdFeB) magnets, which are small in size but produce strong magnetic fields, have become widely available in recent years. Therefore, NdFeB magnets may be associated ...

journal_title：Heart rhythm

authors： Wolber T,Ryf S,Binggeli C,Holzmeister J,Brunckhorst C,Luechinger R,Duru F

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:To reduce inappropriate therapy from implantable cardioverter-defibrillators (ICDs), electrogram morphology discrimination has been developed to improve arrhythmia discrimination without compromising device safety. OBJECTIVES:The purpose of this study was to determine the accuracy of the morphology discrimi...

journal_title：Heart rhythm

authors： Theuns DA,Rivero-Ayerza M,Goedhart DM,van der Perk R,Jordaens LJ

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Cardiac contractility modulation signals are associated with acutely improved hemodynamics, but chronic clinical impact is not defined. OBJECTIVES:The purpose of this randomized, double-blind, pilot study was to determine the feasibility of safely and effectively delivering cardiac contractility modulation ...

journal_title：Heart rhythm

authors： Neelagaru SB,Sanchez JE,Lau SK,Greenberg SM,Raval NY,Worley S,Kalman J,Merliss AD,Krueger S,Wood M,Wish M,Burkhoff D,Nademanee K

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Findings from animal studies and small series of patients support the greater safety of cryoenergy over radiofrequency in the ablation of arrhythmic substrates near the AV node. OBJECTIVES:The purpose of this study was to systematically evaluate the electrophysiologic effects of successive cryoenergy applic...

journal_title：Heart rhythm

authors： Pérez-Castellano N,Villacastín J,Moreno J,Isa R,Ruiz E,Doblado M,Moreno M,Morales R,Macaya C

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The QT interval on the ECG is prolonged by more than 50 marketed drugs, an effect that has been associated with syncope and/or sudden cardiac death due to an arrhythmia. Because changes in heart rate also change the QT interval, it has become standard practice to use a correction formula, such as the Bazett ...

journal_title：Heart rhythm

authors： Indik JH,Pearson EC,Fried K,Woosley RL

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:With the increasing use of implantable cardioverter-defibrillators (ICDs), device complications are becoming more common. Fungal-related ICD infections have rarely been reported, and little is known about the presentation, prevalence, and treatment options for these morbid infections. OBJECTIVES:The purpose...

journal_title：Heart rhythm

authors： Ho IC,Milan DJ,Mansour MC,Mela T,Guy ML,Ruskin JN,Ellinor PT

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Public access defibrillation programs have demonstrated a survival benefit in persons with out-of-hospital cardiac arrest. However, little is known about the effectiveness of early defibrillation in young competitive athletes with sudden cardiac arrest (SCA). OBJECTIVES:The purpose of this study was to inve...

journal_title：Heart rhythm

authors： Drezner JA,Rogers KJ

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Mutations in the RyR2-encoded cardiac ryanodine receptor/calcium release channel and in CASQ2-encoded calsequestrin cause catecholaminergic polymorphic ventricular tachycardia (CPVT1 and CPVT2, respectively). OBJECTIVES:The purpose of this study was to evaluate the extent of genotypic and phenotypic heterog...

journal_title：Heart rhythm

authors： Tester DJ,Arya P,Will M,Haglund CM,Farley AL,Makielski JC,Ackerman MJ

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited. OBJECTIVES:The purpose of this study was to evaluate the effectiveness of ICD therapy in patients with AF en...

journal_title：Heart rhythm

authors： Zareba W,Steinberg JS,McNitt S,Daubert JP,Piotrowicz K,Moss AJ,MADIT II Investigators.

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The population of patients likely to respond to selected pacing algorithms for maintenance of sinus rhythm is unknown. OBJECTIVES:The purpose of this study was to identify patients with specific onset patterns of paroxysmal atrial fibrillation (AF). METHODS:Dual-chamber pacemakers with advanced diagnostic ...

journal_title：Heart rhythm

authors： Yang A,Ruiter J,Pfeiffer D,Esmailzadeh B,Welz A,Hochhäusler M,Nickenig G,Lüderitz B,Lewalter T

更新日期：2006-06-01 00:00:00

abstract：:Wilhelm His Jr. (1863-1934) was a Swiss-born cardiologist and anatomist. In 1893, he discovered the bundle of His-the specialized tissue in the heart that transmits the electrical impulses and helps synchronize contraction. He pioneered studies in cardiac conduction and coined the term "heart block," which he identifi...

journal_title：Heart rhythm

authors： Roguin A

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The ionic mechanisms underlying action potential duration alternans are not established. OBJECTIVES:The purpose of this study was to explore the mechanisms underlying action potential alternans. METHODS:Computer simulations were performed using a model of a single ischemic myocyte. To emulate ischemia, ext...

journal_title：Heart rhythm

authors： Hopenfeld B

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The incidence of atrial tachycardia following Fontan surgery is high, but access to the pulmonary venous atrium, a frequent site of arrhythmia origin, is limited. OBJECTIVES:The purpose of this study is to report our results with a novel transthoracic percutaneous technique that provides direct access to th...

journal_title：Heart rhythm

authors： Nehgme RA,Carboni MP,Care J,Murphy JD

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Genetic testing for long QT syndrome (LQTS) has been available in a research setting for the past decade, and a commercial test has recently become available. However, the costs and effectiveness of genetic testing have not been estimated. OBJECTIVES:The purpose of this study was to conduct a cost-effective...

journal_title：Heart rhythm

authors： Phillips KA,Ackerman MJ,Sakowski J,Berul CI

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The Medtronic EnPulse pacemaker incorporates the new atrial capture management (ACM) algorithm to automatically measure atrial capture thresholds and subsequently manage atrial pacing outputs. OBJECTIVES:The purpose of this study was to evaluate the clinical performance of ACM. METHODS:Two hundred patients...

journal_title：Heart rhythm

authors： Sperzel J,Milasinovic G,Smith TW,Mead H,Brandt J,Haisty WK,Bailey JR,Roelke M,Simonson J,Englund J,Farges E,Compton S

更新日期：2005-11-01 00:00:00

abstract：:Torsades de pointes (TdP) is a potentially lethal arrhythmia that develops as a consequence of amplification of electrical heterogeneities intrinsic to the ventricular myocardium. These heterogeneities exist because of differences in the time course of repolarization of the three predominant cell types that make up th...

journal_title：Heart rhythm

authors： Antzelevitch C

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Atrial tachyarrhythmias (AT) are considered progressive diseases. Several rhythm control therapies for treatment of AT have been proposed. OBJECTIVES:The Italian AT500 Registry was designed to prospectively study long-term AT evolution in patients paced for the brady-tachy form of sinus node disease (BT-SND...

journal_title：Heart rhythm

authors： Padeletti L,Santini M,Boriani G,Botto G,Gulizia M,Molon G,Luzzi G,Senatore G,Giraldi F,Zolezzi F,Pieragnoli P,Pro F,Desanto T,Grammatico A,Italian AT500 Registry Investigators.

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Pericardial effusion, a sign of cardiac perforation, may complicate permanent pacemaker placement. Risk factors for development of post-permanent pacemaker effusion have not been evaluated. OBJECTIVES:The purpose of this study was to determine the predictors of symptomatic pericardial effusion after permane...

journal_title：Heart rhythm

authors： Mahapatra S,Bybee KA,Bunch TJ,Espinosa RE,Sinak LJ,McGoon MD,Hayes DL

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:State-of-the art cardiac pacemakers are protected against radiofrequency signals. Although there have been earlier clinical and in vitro reports of cellular phone interference with implantable devices, only a few studies have been performed in recent years. The ringing phase of digital GSM or PCS cellular ph...

journal_title：Heart rhythm

authors： Trigano A,Blandeau O,Dale C,Wong MF,Wiart J

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:The slow and rapid (I(Kr)) components of I(K) are major determinants of ventricular repolarization. Unlike I(Kr), which is homogeneously expressed across the transmural wall, I(Ks) expression is reduced in midmyocardial cells and presumably contributes significantly to transmural dispersion of repolarization...

journal_title：Heart rhythm

authors： Pajouh M,Wilson LD,Poelzing S,Johnson NJ,Rosenbaum DS

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Although improved quality of life is one of the primary aims of catheter ablation for paroxysmal atrial fibrillation, there is a paucity of published data on this topic. OBJECTIVES:The purpose of this study was to determine the effect of curative catheter ablation on the quality of life of patients with sym...

journal_title：Heart rhythm

authors： Weerasooriya R,Jaïs P,Hocini M,Scavée C,MacLe L,Hsu LF,Sandars P,Garrigue S,Clémenty J,Haïssaguerre M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess the long-term effects of ablation of infarct-related ventricular tachycardia (VT) and the subsequent requirement for implantable cardioverter-defibrillator (ICD) therapy. BACKGROUND:The long-term consequences after initially successful catheter ablation of infarct-rel...

journal_title：Heart rhythm

authors： Segal OR,Chow AW,Markides V,Schilling RJ,Peters NS,Davies DW

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine if there is a difference in commercially available biphasic waveforms. BACKGROUND:Although the superiority of biphasic over monophasic waveforms for external cardioversion of atrial fibrillation (AF) is established, the relative efficacy of available biphasic wavef...

journal_title：Heart rhythm

authors： Alatawi F,Gurevitz O,White RD,Ammash NM,Malouf JF,Bruce CJ,Moon BS,Rosales AG,Hodge D,Hammill SC,Gersh BJ,Friedman PA

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the value of T-wave alternans (TWA) following ventricular extrasystoles in predicting arrhythmia-free survival. BACKGROUND:Stratifying risk for sudden death in patients with coronary disease and moderate left ventricular (LV) dysfunction remains a challenge. We hypothe...

journal_title：Heart rhythm

authors： Narayan SM,Smith JM,Schechtman KB,Lindsay BD,Cain ME

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to identify risk markers in patients with Brugada syndrome. BACKGROUND:Patients with Brugada syndrome who experience syncope or aborted sudden death are at high risk for recurrent lethal arrhythmias. The prognosis and therapeutic approaches in asymptomatic individuals with a Br...

journal_title：Heart rhythm

authors： Yokoi H,Makita N,Sasaki K,Takagi Y,Okumura Y,Nishino T,Makiyama T,Kitabatake A,Horie M,Watanabe I,Tsutsui H

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES/BACKGROUND:Previous in vitro studies have suggested full repolarization of the epicardium coincides with the peak of the T wave (T(peak)) and that of the M cells coincides with the end of the T wave (T(end)). However, in vivo validation of the theory is lacking. METHODS:Monophasic action potentials (MAPs) w...

journal_title：Heart rhythm

authors： Xia Y,Liang Y,Kongstad O,Liao Q,Holm M,Olsson B,Yuan S

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the safety and efficacy of cryoablation in a closed chest canine epicardial ablation model. BACKGROUND:Limitations of radiofrequency energy in the epicardial space warrants investigation of alternative energy sources. METHODS:A linear-tip catheter with a 3-cm freez...

journal_title：Heart rhythm

authors： Lustgarten DL,Bell S,Hardin N,Calame J,Spector PS

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:To explore the mechanism, we tested the hypothesis that premature epicardial stimulation transiently increased the dispersion of repolarization leading to VT. BACKGROUND:Premature stimulation initiated ventricular tachycardia (VT) when applied to the epicardium but not to the endocardium in a canine model o...

journal_title：Heart rhythm

authors： Ueda N,Zipes DP,Wu J

更新日期：2004-12-01 00:00:00

abstract：:Cardiac arrhythmia surgery was initiated in 1968 with the first successful division of an accessory AV connection for the Wolff-Parkinson-White Syndrome. Subsequent surgical procedures included the left atrial isolation procedure and the right atrial isolation procedure for automatic atrial tachycardias, discrete cryo...

journal_title：Heart rhythm

authors： Cox JL

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine if AV delay optimization with continuous-wave Doppler aortic velocity-time integral (VTI) is clinically superior to an empiric program in patients treated with cardiac resynchronization therapy (CRT) for severe heart failure. BACKGROUND:The impact of AV delay progr...

journal_title：Heart rhythm

authors： Sawhney NS,Waggoner AD,Garhwal S,Chawla MK,Osborn J,Faddis MN

更新日期：2004-11-01 00:00:00

abstract：:Quinolone antibiotics have potentially serious proarrhythmic effects. The effects on intracardiac potassium channels result in QT interval prolongation, leading to torsades de pointes. Evidence suggests fluoroquinolones cause QT-mediated proarrhythmia, and weak evidence links ciprofloxacin with QT-mediated arrhythmias...

journal_title：Heart rhythm

authors： Prabhakar M,Krahn AD

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:This study was designed to determine whether ionic currents in right ventricular myocytes from explanted human transplant recipient hearts are related to right ventricular histopathology and function. BACKGROUND:Cardiac action potential duration (APD) is prolonged in ventricular tissues/cells from patients ...

journal_title：Heart rhythm

authors： Li GR,Lau CP,Leung TK,Nattel S

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to ascertain the effects of spatially variable ACh distributions on arrhythmogenesis in a morphologically realistic computer model of canine atria. BACKGROUND:Vagal stimulation releases acetylcholine (ACh), which causes a dose-dependent reduction in action potential duration (APD...

journal_title：Heart rhythm

authors： Vigmond EJ,Tsoi V,Kuo S,Arevalo H,Kneller J,Nattel S,Trayanova N

更新日期：2004-09-01 00:00:00

abstract：:Newer generations of pacemakers and implantable cardioverter defibrillators have enhanced diagnostic features that permit detection and storage of information about the frequency, duration, time of onset, and rate characteristics of multiple consecutive episodes of atrial tachycardia and atrial fibrillation (AF). Para...

journal_title：Heart rhythm

authors： Gillis AM

更新日期：2004-07-01 00:00:00